Details of Drug

Details of Drug

 Drug General Information (ID: D0082)
  Drug Name
Amrinone
  Drug Type Small molecule
  Drug Synonymous
Amrinone; 60719-84-8; inamrinone; Inocor; Wincoram; Cordemcura; Cartonic; Amrinonum [INN-Latin]; Amcoral; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Win-40680; Vesistol; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; WIN 40680; 5-Amino-(3,4'-bipyridin)-6(1H)-one; AWD 08-250; [3,4'-Bipyridin]-6(1H)-one, 5-amino-; UNII-JUT23379TN; 5-amino-3,4'-bipyridin-6(1H)-one; Amrinone lactate; MLS000069829; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; (3,4'-BIPYRIDIN)-6(1H)-ONE, 5-AMINO-; 3-amino-5-pyridin-4-ylpyridin-2-ol; NSC-759805; 3-amino-5-(pyridin-4-yl)pyridin-2-ol; 5-Amino[3,4'-bipyridin]-6(1H)-one; NCGC00164379-01; Amrinona; Amrinonum; CAS-60719-84-8; DSSTox_CID_2603; DSSTox_RID_76655; DSSTox_GSID_22603; Inamrinone (USP); Amcoral (TN); CCRIS 3794; 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one; Amrinone (JAN/INN); Inamrinone [USAN:USP]; EINECS 262-390-0; BRN 0744819; Prestwick_44; Amrinone [INN]; Amrinone,(S); Spectrum_001350; Opera_ID_1054; Prestwick0_000800; Prestwick1_000800; Prestwick2_000800; Prestwick3_000800; Spectrum2_001980; Spectrum3_000956; Spectrum4_001069; Spectrum5_000999; cid_3698; SCHEMBL44012; BSPBio_000940; KBioGR_001398; KBioSS_001830; 5-25-15-00181 (Beilstein Handbook Reference); MLS001074083; DivK1c_000136; SPECTRUM1503084; SPBio_002139; SPBio_002879; BPBio1_001034; CHEBI:2686; GTPL7202; DTXSID9022603; SCHEMBL13457017; BDBM34651; HMS500G18; KBio1_000136; KBio2_001830; KBio2_004398; KBio2_006966; KBio3_002052; C01CE01; NINDS_000136; HMS1570O22; HMS2097O22; HMS2234F12; HMS3264E16; HMS3369J10; HMS3714O22; Pharmakon1600-01503084; BCP12764; HY-B1294; ZINC8673078; Tox21_112110; Tox21_301847; CCG-39487; NSC759805; STK590307; AKOS005512516; Tox21_112110_1; DB01427; KS-5178; MCULE-2781267039; NSC 759805; CID 5281003; IDI1_000136; NCGC00016896-01; NCGC00016896-02; NCGC00016896-03; NCGC00016896-06; NCGC00095984-01; NCGC00255137-01; AC-12186; AC-33137; BA166404; 5-Amino(3,4'-bipyridine)-6-(1H)-one; 5-Amino-(3,4?-bipyridin)-6(1H)-one; 3-Amino-5-(4-pyridinyl)-2(1H)pyridinone; 3-azanyl-5-pyridin-4-yl-1H-pyridin-2-one; CS-0013064; FT-0601595; C75837; D00231; AB00052312-04; AB00052312_05; 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone; 719A848; A832852; Q422724; SR-00000002445; SR-00000002445-2; W-105234; 3-amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one; BRD-K45924332-001-04-4; BRD-K45924332-001-07-7; Amrinone, United States Pharmacopeia (USP) Reference Standard; 216151-27-8
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  Therapeutic Class Cardiovascular Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C10H9N3O
  InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
  InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N
  Canonical SMILES C1=CN=CC=C1C2=CNC(=O)C(=C2)N
  External Link
Pubchem ID 3698

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM042  Additive hypotensive effects
  Relation Graph
 Full list of drugs interacting with Amrinone
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[1]
D0055
 
Amifostine
 
C5H15N2O3PS
 
2141 
Moderate    Inter Info   
[2], [3], [4]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[5]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[6], [7], [8]
D1437
 
Safinamide
 
C17H19FN2O2
 
131682 
Moderate    Inter Info   
[6], [7], [8]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[9]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[10], [11], [12]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[6], [7], [8]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[6], [7], [8]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[13], [14], [15]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[6], [7], [8]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[6], [7], [8]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[6], [7], [8]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[6], [7], [8]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[6], [7], [8]
References
1 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
2 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
3 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
4 Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
5 Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
6 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
7 Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
8 Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
9 Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
10 Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
11 Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
12 Product Information. Inocor (inamrinone). Sanofi Winthrop Pharmaceuticals, New York, NY.
13 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
14 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
15 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]