Details of Drug

Drug General Information (ID: D0054)
Drug Name	Amifampridine
Drug Type	Small molecule
Drug Synonymous	3,4-DIAMINOPYRIDINE; pyridine-3,4-diamine; 3,4-Pyridinediamine; Firdapse; Diamino-3,4 pyridine; 4,5-Diaminopyridine; 3,4-DAP; SC10; amifampridin; Zenas; UNII-RU4S6E2G0J; EINECS 200-220-9; NSC 521760; BRN 0110232; RU4S6E2G0J; OYTKINVCDFNREN-UHFFFAOYSA-N; WT559; NCGC00167560-01; SMR000752913 Click to Show/Hide
Disease Class	8C62: Lambert-Eaton syndrome
Therapeutic Class	Cholinergic Muscle Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C5H7N3
InChI	1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)
InChIKey	OYTKINVCDFNREN-UHFFFAOYSA-N
Canonical SMILES	C1=CN=CC(=C1N)N
External Link
	Pubchem ID	5918
	CAS Number	54-96-6
	CHEBI ID	135948
	TTD ID	D0HE0Y
	INTEDE ID	DR1747

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM037 Additive cholinergic effects BM069 Increased risk of lowers seizure threshold
Relation Graph

Full list of drugs interacting with Amifampridine
Pharmacodynamic additive effects
	Additive cholinergic effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[23], [24]
D0175		Bethanechol	C7H17N2O2+	2370	Moderate		Inter Info	[23], [24]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[23], [24]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[23], [24]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[23], [24]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[23], [24]
D1016		Methacholine	C8H18NO2+	1993	Moderate		Inter Info	[23], [24]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[23], [24]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[23], [24]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[23], [24]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[23], [24]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[23], [24]
	Increased risk of lowers seizure threshold					Drug Num: 175
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[16], [17], [18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[16], [17], [18], [19], [20]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[21], [14], [13], [22]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[23], [24]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[23], [24]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[25], [23], [24]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[23], [24]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[23], [24]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[23], [24]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[23], [24]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[23], [24]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[25], [23], [24]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[25], [23], [24]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[23], [24]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[25], [23], [24]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[25], [23], [24]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[25], [23], [24]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[23], [24]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[23], [24]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[25], [23], [24]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[23], [24]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[23], [24]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[23], [24]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[23], [24]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[25], [23], [24]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[23], [24]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[23], [24]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[25], [23], [24]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[25], [23], [24]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[23], [24]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[25], [23], [24]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[25], [23], [24]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[25], [23], [24]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[25], [23], [24]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[23], [24]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[23], [24]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[23], [24]
D0401		Cycloserine	C3H6N2O2	6234	Moderate		Inter Info	[23], [24]
D0412		Dalfampridine	C5H6N2	1727	Moderate		Inter Info	[23], [24]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[25], [23], [24]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[23], [24]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[23], [24]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[23], [24]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[25], [23], [24]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[23], [24]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[23], [24]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[23], [24]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[23], [24]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[23], [24]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[25], [23], [24]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[25], [23], [24]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[23], [24]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[23], [24]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[23], [24]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[25], [23], [24]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[23], [24]
D0596		Ertapenem	C22H25N3O7S	150610	Moderate		Inter Info	[23], [24]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[25], [23], [24]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[23], [24]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[23], [24]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[23], [24]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[25], [23], [24]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[25], [23], [24]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[23], [24]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[25], [23], [24]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[25], [23], [24]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[25], [23], [24]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[25], [23], [24]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[25], [23], [24]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[23], [24]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[23], [24]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[23], [24]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[25], [23], [24]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[25], [23], [24]
D0794		Imipenem	C12H17N3O4S	104838	Moderate		Inter Info	[23], [24]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[25], [23], [24]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[23], [24]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[23], [24]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[23], [24]
D0825		Interferon alfa-n3	NA	NA	Moderate		Inter Info	[23], [24]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[23], [24]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[23], [24]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[23], [24]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[23], [24]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[23], [24]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[25], [23], [24]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[25], [23], [24]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[23], [24]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[23], [24]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[23], [24]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[34], [35], [36]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[25], [23], [24]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[25], [23], [24]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[23], [24]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[23], [24]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[23], [24]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[23], [24]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[25], [23], [24]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[23], [24]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[23], [24]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[25], [23], [24]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[23], [24]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[25], [23], [24]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[23], [24]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[23], [24]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[23], [24]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[23], [24]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[23], [24]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[23], [24]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[25], [23], [24]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[23], [24]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[23], [24]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[23], [24]
D1093		Muromonab	NA	NA	Moderate		Inter Info	[23], [24]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[23], [24]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[23], [24]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[23], [24]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[23], [24]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[25], [23], [24]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[25], [23], [24]
D1183		Opium	NA	NA	Moderate		Inter Info	[23], [24]
D1194		Oxamniquine	C14H21N3O3	4612	Moderate		Inter Info	[23], [24]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[23], [24]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[23], [24]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[23], [24]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[25], [23], [24]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[23], [24]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[23], [24]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[23], [24]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[23], [24]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[23], [24]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[23], [24]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[25], [23], [24]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[23], [24]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[23], [24]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[23], [24]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[23], [24]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[37], [38], [25]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[25], [23], [24]
D1297		Piperazine	C4H10N2	4837	Moderate		Inter Info	[23], [24]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[37], [38], [25]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[23], [24]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[23], [24]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[25], [23], [24]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[25], [23], [24]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[25], [23], [24]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[23], [24]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[25], [23], [24]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[25], [23], [24]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[23], [24]
D1406		Rimantadine	C12H21N	5071	Moderate		Inter Info	[23], [24]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[25], [23], [24]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[25], [23], [24]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[23], [24]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[37], [38], [25]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[25], [23], [24]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[23], [24]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[23], [24]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[23], [24]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[23], [24]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[25], [23], [24]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[23], [24]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[23], [24]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[25], [23], [24]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[23], [24]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[25], [23], [24]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[25], [23], [24]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[25], [23], [24]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[23], [24]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[25], [23], [24]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[23], [24]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[23], [24]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[25], [23], [24]

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