Details of Drug

Details of Drug

 Drug General Information (ID: D0050)
  Drug Name
Alvimopan
  Drug Type Small molecule
  Drug Synonymous
Alvimopan anhydrous; LY 246736; LY246736; Adl 8-2698; Entereg (TN); Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine; Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
    Click to Show/Hide
  Disease Class DE2Z: Digestive system disease
  Therapeutic Class Analgesics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C25H32N2O4
  InChI 1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1
  InChIKey UPNUIXSCZBYVBB-JVFUWBCBSA-N
  Canonical SMILES CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O
  External Link
Pubchem ID 5488548
CAS Number 156053-89-3
CHEBI ID 135686
TTD ID D0D7KC

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM011  Transporter induction
BM096  Antagonize the effect of opioid receptor agonists
  Relation Graph
 Full list of drugs interacting with Alvimopan
      Affected cellular transport
   Transporter inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[7]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[8]
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[3], [4], [5], [6]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of opioid receptor agonists Drug Num:  22
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Major    Inter Info   
[1], [2]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[1], [2]
D1183
 
Opium
 
NA
 
NA
Major    Inter Info   
[1], [2]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Major    Inter Info   
[1], [2]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Major    Inter Info   
[1], [2]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Major    Inter Info   
[1], [2]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Major    Inter Info   
[1], [2]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Major    Inter Info   
[1], [2]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Major    Inter Info   
[1], [2]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Major    Inter Info   
[1], [2]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Major    Inter Info   
[1], [2]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Major    Inter Info   
[1], [2]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[1], [2]
D0923
 
Levorphanol
 
C17H23NO
 
5359272 
Major    Inter Info   
[1], [2]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Major    Inter Info   
[1], [2]
D1017
 
Methadone
 
C21H27NO
 
4095 
Major    Inter Info   
[1], [2]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Major    Inter Info   
[1], [2]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Major    Inter Info   
[1], [2]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Major    Inter Info   
[1], [2]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Major    Inter Info   
[1], [2]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Major    Inter Info   
[1], [2]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[1], [2]
References
1 Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
2 Product Information. Entereg (alvimopan). GlaxoSmithKline, Research Triangle Park, NC.
3 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
4 Cerner Multum, Inc. "Australian Product Information.".
5 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
7 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
8 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.