Details of Drug

Drug General Information (ID: D0047)
Drug Name	Alteplase
Drug Type	Protein/peptide
Drug Synonymous	Activase (TN) Click to Show/Hide
Disease Class	BB00: Pulmonary thromboembolism
Therapeutic Class	Thrombolytics
External Link
External Link	TTD ID	D07BQE

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM048 Increased risk of angioedema/anaphylactoid reactions BM050 Increased risk of bleeding BM085 Antagonize the effect of antithrombotic agents
Relation Graph

Full list of drugs interacting with Alteplase
Pharmacodynamic additive effects
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[1], [2], [11]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[1], [2], [11]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[1], [2], [11]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[1], [2], [11]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[1], [2], [11]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[1], [2], [11]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[1], [2], [11]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[1], [2], [11]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[1], [2], [11]
	Increased risk of bleeding					Drug Num: 121
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[4]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[2], [15]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[23], [24], [25]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [26]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[27]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[28]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[2], [29]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [30]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D0415		Danaparoid	NA	NA	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[31]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[32], [33]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[2], [34]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[35]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[5], [12], [13]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[36]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[37]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[38], [7], [8], [39], [10], [11], [12], [13], [14], [40], [41], [42]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[43]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[44], [45], [2], [46]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [32], [47]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[32], [48]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [49]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[50]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[2], [51]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[52]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [53], [54]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[55]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[56]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3]
D1613		Tositumomab	NA	NA	Major		Inter Info	[57], [58]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[57], [58]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[59]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[32]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[23], [24], [25]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[25]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[7], [10], [14]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[63], [64], [65]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[63], [64], [65]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[66]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[106]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[32], [107]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[63], [64], [65]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[63], [64], [65]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[63], [64], [65]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[63], [64], [65]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[63], [64], [65]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[63], [64], [65]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[63], [64], [65]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0711		Garlic	NA	NA	Moderate		Inter Info	[108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[113], [123], [124], [117], [120]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[125], [126], [127], [128], [110], [129], [130], [111], [113], [114], [131], [123], [132], [117], [133], [134], [135], [120], [136]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[137], [111], [113], [138], [114], [139], [117], [120], [140]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[141]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[63], [64], [65]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[2], [142], [143]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[63], [64], [65]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[63], [64], [65]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[63], [64], [65]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[63], [64], [65]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[63], [64], [65]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[63], [64], [65]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[63], [64], [65]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[63], [64], [65]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[63], [64], [65]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[63], [64], [65]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[144]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [145]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[2], [142], [143]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[63], [64], [65]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[32], [146]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[147], [148]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[7], [10], [14]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[63], [64], [65]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[63], [64], [65]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[66]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[7], [10], [14]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[63], [64], [65]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[63], [64], [65]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2], [149]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[63], [64], [65]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[7], [8], [10], [11], [12], [13], [67], [14]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[66]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[68], [69], [70], [71], [1], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105]
D0253		Capsicum	NA	NA	Minor		Inter Info	[113]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[113], [150], [117]
D0368		Clove	NA	NA	Minor		Inter Info	[113], [151], [152], [153]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[154], [113], [155]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0060		Aminocaproic acid	C6H13NO2	564	Moderate		Inter Info	[60], [61], [62]
D1741		Aprotinin	C284H432N84O79S7	16130295	Moderate		Inter Info	[60], [61], [62]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[2]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[2]
D1619		Tranexamic acid	C8H15NO2	5526	Moderate		Inter Info	[60], [61], [62]

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23	Product Information. Acova (argatroban) SmithKline Beecham, Philadelphia, PA.
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25	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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27	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
28	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
29	Product Information. Kengreal (cangrelor). The Medicines Company, Parsippany, NJ.
30	Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
31	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
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34	Product Information. Defitelio (defibrotide). Jazz Pharmaceuticals, Palo Alto, CA.
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47	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
48	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
49	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
50	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
51	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
52	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
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54	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
55	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
56	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
57	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
58	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
59	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
60	Product Information. LYSTEDA (tranexamic acid). Xanodyne Pharmaceuticals Inc, Newport, KY.
61	Product Information. Cyklokapron (tranexamic acid). Pharmacia and Upjohn, Kalamazoo, MI.
62	Product Information. Trasylol (aprotinin). Bayer, West Haven, CT.
63	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
64	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
65	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
66	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
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90	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
91	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
92	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
93	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
94	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
95	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
96	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
97	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
98	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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146	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
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