Details of Drug

Details of Drug

 Drug General Information (ID: D0046)
  Drug Name
Alprostadil
  Drug Type Small molecule
  Drug Synonymous
Prostaglandin E1; alprostadil; 745-65-3; PGE1; Muse; Edex; Caverject; Prostin VR; Alprostadilum; Femprox; Befar; Vitaros; Prostandin; Liprostin; PGE-1; Prink (TN); Befar (TN); Prostavasin; Vasaprostan; MR-256; Minprog; UNII-F5TD010360; Alprostadil(Caverject); CHEMBL495; (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; Prostivas; Lipoprost; 11alpha,15alpha-Dihydroxy-9-oxo-13-trans-prostenoic acid; (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate; FemLife; RayVa; Sugiran; Viridal; MR 256; PGE1 Oligomer; BML1-F06; Caverject (TN); Edex (TN); HEI-507; Muse (TN); Prostin VR pediatric (TN); U-10136; Alprostadil (JP15/USP/INN); Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-, homopolymer; (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid; (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid; 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid; Lipo-alprostadil
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  Disease Class HA00-HA01: Sexual dysfunction; BD54: Diabetic foot ulcer
  Therapeutic Class Vasodilator Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C20H34O5
  InChI 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
  InChIKey GMVPRGQOIOIIMI-DWKJAMRDSA-N
  Canonical SMILES CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
  External Link
Pubchem ID 5280723
CAS Number 745-65-3
CHEBI ID 15544
TTD ID D0I4DQ
INTEDE ID DR1923
VARIDT ID DR00210

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM042  Additive hypotensive effects
BM050  Increased risk of bleeding
BM089  Antagonize the effect of antihypertensive agents
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Alprostadil
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  22
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[1], [2], [3]
D0128
 
Avanafil
 
C23H26ClN7O3
 
9869929 
Moderate    Inter Info   
[4], [5], [6]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[7], [8], [9]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[7], [8], [9]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[7], [8], [9]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[8], [10], [11]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[8], [10], [11]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[18], [19], [20]
D1148
 
Nitrous acid
 
HNO2
 
24529 
Moderate    Inter Info   
[21], [22], [23]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[24]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Moderate    Inter Info   
[25]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[8], [10], [11]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[4], [5], [6]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[26], [27], [28]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[1], [2], [3]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[1], [2], [3]
D0459
 
Dexmedetomidine
 
C13H16N2
 
5311068 
Moderate    Inter Info   
[7], [29], [30]
D1848
 
Minoxidil (topical)
 
C9H15N5O
 
4201 
Moderate    Inter Info   
[31], [32]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Moderate    Inter Info   
[4], [5], [6]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[8], [10], [11]
D0711
 
Garlic
 
NA
 
NA
Minor    Inter Info   
[35], [36]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Minor    Inter Info   
[37], [38]
   Increased risk of bleeding Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[12], [7], [8], [13]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Moderate    Inter Info   
[17]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0926
 
Licorice
 
C42H62O16Zn
 
163463 
Moderate    Inter Info   
[14], [15], [16]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[33], [34]
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