Details of Drug

Drug General Information (ID: D0031)
Drug Name	Alectinib
Drug Type	Small molecule
Drug Synonymous	1256580-46-7; CH5424802; CH 5424802; AF-802; Alecensa; UNII-LIJ4CT1Z3Y; AF 802; LIJ4CT1Z3Y; Alectinib (CH5424802); 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; CHEMBL1738797; AF802; 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-Yl)piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5h-Benzo[b]carbazole-3-Carbonitrile; 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile; AK170451; C30H34N4O2; Alectinib; 9-ethyl-6,6-dimethyl- Click to Show/Hide
Disease Class	2C25: Lung cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C30H34N4O2
InChI	1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChIKey	KDGFLJKFZUIJMX-UHFFFAOYSA-N
Canonical SMILES	CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C
External Link
	Pubchem ID	49806720
	CAS Number	1256580-46-7
	CHEBI ID	90936
	TTD ID	D0U3SY

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Alectinib
Pharmacodynamic additive effects
	Increased risk of bradycardia					Drug Num: 60
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [3]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[11], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[13]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[26]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[27]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[11], [12]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[11], [12]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[11], [12]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[11], [12]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[11], [12]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[11], [12]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[11], [12]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[11], [12]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[11], [12]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[11], [12]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[11], [12]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[11], [12]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[11], [12]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[11], [12]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[11], [12]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[11], [12]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[11], [12]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[11], [12]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[11], [12]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[39], [40]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[11], [12]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[11], [12]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[11], [12]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[11], [12]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[11], [12]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[11], [12]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[11], [12]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[11], [12]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[11], [12]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[11], [12]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[11], [12]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[11], [12]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[11], [12]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[11], [12]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[11], [12]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[11], [12]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[11], [12]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[11], [12]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[11], [12]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[11], [12]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[11], [12]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[11], [12]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[11], [12]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[11], [12]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[11], [12]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[11], [12]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[11], [12]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[11], [12]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[11], [12]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[11], [12]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[11], [12]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[11], [12]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[11], [12]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[11], [12]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[11], [12]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[6], [7], [8]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[9]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[10]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[6], [7], [8]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [17], [28], [29], [30]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[32]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[33]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[17], [34]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[35]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[36], [37]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2], [17], [38]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[41]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[42], [43], [44], [45]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[42], [43], [44], [45]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[49]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[42], [43], [44], [45]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[52], [53]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[17], [54]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[4], [5]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[2], [17], [31]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[2], [46], [4], [47], [48]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[2], [17], [31]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[50], [17], [51]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[17], [46], [4], [55]

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55	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.

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