Details of Drug

Drug General Information (ID: D0028)
Drug Name	Albendazole
Drug Type	Small molecule
Drug Synonymous	Albendazol; Albendazolum; Albendoral; Albenza; Bendapar; Bilutac; Digezanol; Disthelm; Endoplus; Eskazole; Gascop; Lurdex; Metiazol; Proftril; Valbazen; Zental; Zentel; Albendazole Armstrong Brand; Albendazole Diba Brand; Albendazole Fustery Brand; Albendazole Hormona Brand; Albendazole Liferpal Brand; Albendazole Monohydrochloride; Albendazole Pfizer Brand; Albendazole Sanicoopa Brand; Albendazole Valdecasas Brand; Armstrong Brand of Albendazole; Diba Brand of Albendazole; Fustery Brand of Albendazole; Hormona Brand of Albendazole; Liferpal Brand of Albendazole; Mediamix V Disthelm; Noe Socopharm Brand of Albendazole; Pfizer Brand of Albendazole; Sanicoopa Brand of Albendazole; SmithKline Beecham Brand of Albendazole; Valdecasas Brand of Albendazole; SKF 62979; SKF62979; Albendazol [INN-Spanish]; Albendazole Noe-Socopharm Brand; Albendazolum [INN-Latin]; Albenza (TN); Disthelm, Mediamix V; Eskazole (TN); Monohydrochloride, Albendazole; Noe-Socopharm Brand of Albendazole; SK&F 62979; SK&F62979; SKF-62979; Smith Kline & French Brand of Albendazole; V Disthelm, Mediamix; Zentel (TN); SK&F-62979; Albendazole (JAN/USP/INN); Albendazole [USAN:INN:BAN:JAN]; Albenza, Eskazole, Zentel, Andazol, Albendazole; Methyl 5-(propylthio)-2-benzimidazolecarbamate; Methyl [5-(Propylthio)benzimidazol-2-yl]carbamate; Methyl-5-[propylthio]-2-benzimidazole carbamate; [5-(Propylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester; Methyl 5-(propyl-thio)-2-benzimidazolecarbamate; Methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate; Methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate; Methyl [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate; [5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester; MethylN-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate; Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester; Methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate; CARBAMIC ACID, (5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL)-, METHYL ESTER; Methyl [(2Z)-5-(propylsulfanyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]carbamate; ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle; ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French]; (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester; (5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester; 5-(Propylthio)-2-carbomethoxyaminobenzimidazole Click to Show/Hide
Disease Class	1F90: Parasitic worm infestation
Therapeutic Class	Antiprotozoal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H15N3O2S
InChI	1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChIKey	HXHWSAZORRCQMX-UHFFFAOYSA-N
Canonical SMILES	CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
External Link
	Pubchem ID	2082
	CAS Number	54965-21-8
	CHEBI ID	16664
	TTD ID	D00KVO
	INTEDE ID	DR0055
	VARIDT ID	DR01323

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects
Relation Graph

Full list of drugs interacting with Albendazole
Affected cellular transport
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[40], [41], [42]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[5]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[6], [7], [8]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[10], [11]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[16]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[20]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[21]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[23], [24]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[25]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[26]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[29]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [33]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[6], [7], [8]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[10], [11]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[36]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[39]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1], [43]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[44], [13], [45], [46], [47], [48], [49], [50], [51]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[52]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[53]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13], [1], [54]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[55]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[56]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[57]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[13], [1], [59], [60]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[61]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [76], [77]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[15]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[81], [82]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [83]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[88]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[91]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[92], [93]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[95]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[13], [1], [97]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[98]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[13], [1], [100]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[103], [104], [105], [106], [107]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[108], [109]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[110]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[111]
	CYP450 enzyme induction					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[1], [9]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[12]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[13], [1], [14], [15]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[17]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[18]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[19]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [22]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[13], [27]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[28]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[30], [13], [1], [31]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[32]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[58]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[64], [65], [66]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [67]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[78], [79]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [80]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[13], [1], [86]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[13], [1], [87], [86]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[89]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[90]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [94]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [101], [102]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [1], [112], [113]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[13], [1], [86]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[114], [115], [116], [117], [118]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[119]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[114], [115], [116], [117], [118]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[120], [121], [122], [123]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[13], [34], [35]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[13], [34], [35]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[84], [85]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[84], [85]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[84], [85]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[62]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[68]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[96]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [3], [4]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[13], [1], [37], [38]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[63]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[13], [1], [37], [38]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[99]

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91	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
92	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
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94	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
95	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
96	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
97	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
98	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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110	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
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112	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
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