Details of Drug

Drug General Information (ID: D0026)
Drug Name	Afatinib
Drug Type	Small molecule
Drug Synonymous	Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens Click to Show/Hide
Disease Class	2C25: Lung cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C24H25ClFN5O3
InChI	1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Canonical SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
External Link
	Pubchem ID	10184653
	CAS Number	850140-72-6
	CHEBI ID	61390
	TTD ID	D05UFG
	VARIDT ID	DR00354

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM022 CYP450 enzyme induction BM023 UGT induction BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Afatinib
Affected cellular transport
	Transporter inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [2]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[1], [12], [13]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[26]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[1], [27]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[12], [28]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[29]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[30]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[31]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[12], [32]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[34]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[35]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[44]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[1], [45]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[35]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[46]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[12], [47]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[48]
	Transporter induction					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[11]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[11]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[11]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[11]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[11]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[11]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[11]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[11]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[11]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[11]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[11]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[11]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[6], [61], [11]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[11]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[11]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[11]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[12], [40]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[3]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[6], [7], [8]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[9]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[10]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[6], [7], [8]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [12], [17], [18], [19], [20], [21], [22], [23], [24]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[12], [25]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[33]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [12], [41], [42], [43]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [12], [17], [18], [19], [20], [21], [22], [23], [24]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[14], [15], [16], [1], [12], [17], [18], [19], [20], [21], [22], [23], [24]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[50]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[51]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[52]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[53], [54]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [12], [55]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[36], [37], [38], [39]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[12], [56]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[60]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[14], [15], [16], [1], [12], [17], [18], [19], [20], [21], [22], [23], [24]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[62], [63]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[12], [64]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[4], [5]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[1], [12], [49]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[1], [57], [4], [58], [59]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[1], [12], [49]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[12], [57], [4], [65]

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22	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
23	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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30	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
31	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
32	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
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65	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.

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