Details of Drug

Details of Drug

 Drug General Information (ID: D0024)
  Drug Name
Adapalene (topical)
  Drug Type Small molecule
  Drug Synonymous
Adaferin; Adapaleno; Adapalenum; Differin; Differine; CD 271; CD271; Adaferin (TN); Adapaleno [INN-Spanish]; Adapalenum [INN-Latin]; CD-271; Differin (TN); Differin, Adapalene; KS-1196; Adapalene [USAN:BAN:INN]; Adapalene (JAN/USAN/INN); 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid; 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid; 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid; 6-[3-(adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid
    Click to Show/Hide
  Disease Class ED80: Acne vulgaris
  Therapeutic Class Dermatologic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C28H28O3
  InChI 1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
  InChIKey LZCDAPDGXCYOEH-UHFFFAOYSA-N
  Canonical SMILES COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
  External Link
Pubchem ID 60164
CAS Number 106685-40-9
CHEBI ID 31174
TTD ID D0JC9N

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM075  Increased risk of photosensitivity reactions
BM079  Increased risk of skin rash
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Adapalene (topical)
      Pharmacodynamic additive effects
   Increased risk of photosensitivity reactions Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0062
 
Aminolevulinic acid
 
C5H9NO3
 
137 
Major    Inter Info   
[1], [2]
D0063
 
Aminolevulinic acid (topical)
 
C5H9NO3
 
137 
Moderate    Inter Info   
[3], [4], [5]
D1028
 
Methoxsalen
 
C12H8O4
 
4114 
Moderate    Inter Info   
[3], [9], [10]
D1033
 
Methyl aminolevulinate (topical)
 
C6H11NO3
 
157922 
Moderate    Inter Info   
[3], [4], [5]
D1314
 
Porfimer sodium
 
C68H74N8O11
 
135577896 
Moderate    Inter Info   
[11], [4], [12]
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[4], [9], [13]
   Increased risk of skin rash Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0863
 
Isotretinoin
 
C20H28O2
 
5282379 
Moderate    Inter Info   
[4], [8]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1746
 
Benzoyl peroxide (topical)
 
C14H10O4
 
7187 
Moderate    Inter Info   
[6], [7]
D1850
 
Octasulfur (topical)
 
S8
 
66348 
Moderate    Inter Info   
[6], [7]
D1878
 
Resorcinol (topical)
 
C6H6O2
 
5054 
Moderate    Inter Info   
[6], [7]
D1883
 
Salicylic acid (topical)
 
C7H6O3
 
338 
Moderate    Inter Info   
[6], [7]
References
1 Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2 Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3 Cerner Multum, Inc. "Australian Product Information.".
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
6 Product Information. Retin-A (tretinoin). Ortho Pharmaceutical Corporation, Raritan, NJ.
7 Product Information. Tazorac (tazarotene topical). Allergan Inc, Irvine, CA.
8 Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
9 Multum Information Services, Inc. Expert Review Panel.
10 Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
11 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
12 Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
13 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.