Drug General Information (ID: D0007)
  Drug Name
Abiraterone
  Drug Type Small molecule
  Drug Synonymous
Abiraterone (AR inhibitor)
    Click to Show/Hide
  Disease Class 2C82: Prostate cancer
  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H31NO
  InChI 1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1
  InChIKey GZOSMCIZMLWJML-VJLLXTKPSA-N
  Canonical SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
  External Link
Pubchem ID 132971
CAS Number 154229-19-3
CHEBI ID 68642
TTD ID D02STN

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM055  Increased risk of hepatotoxicity
BM076  Increased risk of prolong QT interval
BM081  Increased risk of ventricular arrhythmias
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Abiraterone
      Affected cellular transport
   Transporter inhibition Drug Num:  10
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Major    Inter Info   
[8], [14], [15], [16]
D0739
 
Grazoprevir
 
C38H50N6O9S
 
44603531 
Major    Inter Info   
[8], [21], [22]
D0182
 
Binimetinib
 
C17H15BrF2N4O3
 
10288191 
Moderate    Inter Info   
[11], [8], [206]
D0963
 
Lusutrombopag
 
C29H32Cl2N2O5S
 
49843517 
Moderate    Inter Info   
[41]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[277], [21], [278]
D1407
 
Rimegepant
 
C28H28F2N6O3
 
51049968 
Moderate    Inter Info   
[279]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[281]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[323], [324], [325], [326]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[323], [325], [326]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[323], [324], [325], [326]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  147
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[2]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Major    Inter Info   
[4], [5], [6]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Major    Inter Info   
[7]
D0559
 
Eliglustat
 
C23H36N2O4
 
23652731 
Major    Inter Info   
[17], [18]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[30], [18]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[11], [32]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[45]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Major    Inter Info   
[11], [8], [47]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Major    Inter Info   
[4], [5]
D0947
 
Loperamide
 
C29H33ClN2O2
 
3955 
Major    Inter Info   
[112], [113], [114], [115], [116], [117]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Major    Inter Info   
[11], [8], [132]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Major    Inter Info   
[10], [11], [8], [133], [134], [18]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Major    Inter Info   
[145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [18], [171], [172], [173], [174], [175], [176], [177], [178]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[181]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Moderate    Inter Info   
[182], [183]
D0038
 
Aliskiren
 
C30H53N3O6
 
5493444 
Moderate    Inter Info   
[10], [8], [184], [185]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[8], [186], [183]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Moderate    Inter Info   
[8], [205]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[210], [13], [211]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[11], [8], [212]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[214]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[10], [8], [2]
D0427
 
Dasabuvir
 
C26H27N3O5S
 
56640146 
Moderate    Inter Info   
[216], [217], [2]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[218]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[220]
D0562
 
Eluxadoline
 
C32H35N5O5
 
11250029 
Moderate    Inter Info   
[221]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[222], [223], [224]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[225]
D0866
 
Istradefylline
 
C20H24N4O4
 
5311037 
Moderate    Inter Info   
[227]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[27], [28]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[11], [8], [228]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[229]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[233]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[234]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[235]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[11], [8], [236], [183]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[237]
D1139
 
Nintedanib
 
C31H33N5O4
 
135423438 
Moderate    Inter Info   
[238]
D1306
 
Polatuzumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[272]
D1324
 
Pralsetinib
 
C27H32FN9O2
 
129073603 
Moderate    Inter Info   
[273]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[11], [280]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[282]
D1496
 
Sonidegib
 
C26H26F3N3O3
 
24775005 
Moderate    Inter Info   
[285]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[8], [133], [286]
D1663
 
Ubrogepant
 
C29H26F3N5O3
 
68748835 
Moderate    Inter Info   
[288]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Moderate    Inter Info   
[289]
D1686
 
Velpatasvir
 
C49H54N8O8
 
67683363 
Moderate    Inter Info   
[10], [8], [2]
D1718
 
Zanubrutinib
 
C27H29N5O3
 
135565884 
Moderate    Inter Info   
[290]
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[2]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[11], [8], [297], [298], [299], [300], [301], [302]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[304], [183], [305]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[2]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[10], [8], [2]
D0308
 
Cevimeline
 
C10H17NOS
 
83898 
Moderate    Inter Info   
[307]
D0323
 
Chlorpheniramine
 
C16H19ClN2
 
2725 
Moderate    Inter Info   
[2]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[2]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[2]
D0376
 
Cobimetinib
 
C21H21F3IN3O2
 
16222096 
Moderate    Inter Info   
[309]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[310], [311], [312], [313], [314], [315], [18], [316], [317], [318], [319], [320], [321]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[322], [183]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[2]
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Moderate    Inter Info   
[2]
D0466
 
Dextromethorphan
 
C18H25NO
 
5360696 
Moderate    Inter Info   
[11], [8], [327], [33], [183], [2]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[328], [2], [329]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[11], [8], [330]
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Moderate    Inter Info   
[331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[2]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[2]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[356], [357]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Moderate    Inter Info   
[338], [340], [351]
D0593
 
Ergotamine
 
C33H35N5O5
 
8223 
Moderate    Inter Info   
[331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Moderate    Inter Info   
[360], [183]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Moderate    Inter Info   
[2]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[2]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Moderate    Inter Info   
[2]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[2]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Moderate    Inter Info   
[11], [8], [362], [363]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[2]
D0745
 
Guanfacine
 
C9H9Cl2N3O
 
3519 
Moderate    Inter Info   
[8], [364]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[2]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[10], [11], [8], [365], [366], [367], [368]
D0846
 
Irinotecan (liposomal)
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[11], [8], [365]
D0863
 
Isotretinoin
 
C20H28O2
 
5282379 
Moderate    Inter Info   
[10], [8], [2]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[2]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Moderate    Inter Info   
[328], [2], [329]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[2]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[2]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Moderate    Inter Info   
[338], [340], [351]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Moderate    Inter Info   
[338], [340], [351]
D1046
 
Metoclopramide
 
C14H22ClN3O2
 
4168 
Moderate    Inter Info   
[2]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[2]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Moderate    Inter Info   
[2]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[2]
D1087
 
Montelukast
 
C35H36ClNO3S
 
5281040 
Moderate    Inter Info   
[370], [371]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[2]
D1143
 
Nitisinone
 
C14H10F3NO5
 
115355 
Moderate    Inter Info   
[10], [11], [8]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[2]
D1194
 
Oxamniquine
 
C14H21N3O3
 
4612 
Moderate    Inter Info   
[2]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[376], [377], [11], [378], [379], [380], [381], [382]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[376], [377], [11]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Moderate    Inter Info   
[2]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[2]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[385], [386], [387], [388], [389], [390], [391], [392], [393]
D1299
 
Pirfenidone
 
C12H11NO
 
40632 
Moderate    Inter Info   
[8], [394], [18]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[2]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[2]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[2]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[2]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[2]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Moderate    Inter Info   
[2]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[2]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[405], [406], [407], [408], [393]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[2]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[409], [410], [411], [412], [413], [391], [393]
D1534
 
Tamsulosin
 
C20H28N2O5S
 
129211 
Moderate    Inter Info   
[414], [415], [416], [18]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[2]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[2]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[418], [419], [420]
D1611
 
Torasemide
 
C16H20N4O3S
 
41781 
Moderate    Inter Info   
[423], [424], [425]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[11], [427], [8], [187], [188], [189], [190], [191], [428], [192], [193], [2], [429]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Moderate    Inter Info   
[2]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[430]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Moderate    Inter Info   
[10], [8], [2]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[2]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[2]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[2]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[2]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Minor    Inter Info   
[2]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Minor    Inter Info   
[2]
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Minor    Inter Info   
[431]
D0518
 
Doravirine
 
C17H11ClF3N5O3
 
58460047 
Minor    Inter Info   
[432]
D1104
 
Naloxegol
 
C34H53NO11
 
56959087 
Minor    Inter Info   
[433]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Minor    Inter Info   
[2]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Minor    Inter Info   
[2]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Minor    Inter Info   
[2]
D0208
 
Brivaracetam
 
C11H20N2O2
 
9837243 
Minor    Inter Info   
[8], [434]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Minor    Inter Info   
[2]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Minor    Inter Info   
[2]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Minor    Inter Info   
[435], [18], [436], [437]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Minor    Inter Info   
[2]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Minor    Inter Info   
[2]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Minor    Inter Info   
[2]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Minor    Inter Info   
[2]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Minor    Inter Info   
[2]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Minor    Inter Info   
[2]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Minor    Inter Info   
[2]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Minor    Inter Info   
[445], [446], [18]
   CYP450 enzyme induction Drug Num:  18
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[2]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Major    Inter Info   
[27], [28], [2]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[2]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[2]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[2]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[2]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[2]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[2]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[27], [28], [2]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[2]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[2]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[215]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[11], [219]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[11], [8], [283]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[11], [8], [284], [283]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[8], [287]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[11], [8], [373], [374]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[11], [8], [283]
      Pharmacodynamic additive effects
   Increased risk of hepatotoxicity Drug Num:  20
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[35]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[10], [43], [44]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[10], [43], [44]
D1073
 
Mipomersen
 
C230H324N67O122P19S19
 
118984467 
Major    Inter Info   
[130]
D0113
 
Asparaginase Erwinia chrysanthemi
 
NA
 
NA
Moderate    Inter Info   
[194], [195], [196], [11], [8], [197], [198], [199], [200], [201], [202], [203], [204]
D0232
 
Calaspargase pegol
 
NA
 
NA
Moderate    Inter Info   
[194], [195], [196], [11], [8], [197], [198], [199], [200], [201], [202], [203], [204]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[8], [213]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[226]
D1239
 
Peginterferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[266], [267], [268], [269]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[11], [8], [274], [275], [276]
D0114
 
Asparaginase Escherichia coli
 
NA
 
NA
Moderate    Inter Info   
[194], [195], [196], [11], [8], [197], [198], [303], [200], [201], [202], [203], [204]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[308]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[358], [359]
D0826
 
Interferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[266], [267], [268], [269]
D0827
 
Interferon beta-1b
 
NA
 
NA
Moderate    Inter Info   
[266], [267], [268], [269]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[8], [369]
D1106
 
Naltrexone
 
C20H23NO4
 
5360515 
Moderate    Inter Info   
[372]
D1234
 
Pegaspargase
 
C14H19NO
 
436058 
Moderate    Inter Info   
[194], [195], [196], [11], [8], [197], [198], [199], [200], [201], [202], [203], [204]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[421], [422]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[8], [426]
   Increased risk of prolong QT interval Drug Num:  129
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Major    Inter Info   
[1]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Major    Inter Info   
[3]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Major    Inter Info   
[8], [9]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[10], [11], [8], [12]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Major    Inter Info   
[13]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Major    Inter Info   
[25]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Major    Inter Info   
[26]
D0965
 
Macimorelin
 
C26H30N6O3
 
9804938 
Major    Inter Info   
[29]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Major    Inter Info   
[31]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Major    Inter Info   
[33]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Major    Inter Info   
[10], [11], [8], [34]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Major    Inter Info   
[10], [11], [8], [37], [38], [39], [40], [41]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Major    Inter Info   
[8], [42]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Major    Inter Info   
[10], [11], [8], [46]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[10], [11], [8], [48], [49], [50], [51], [52], [53], [54], [55], [56], [41]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Major    Inter Info   
[10], [11], [8], [57]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Major    Inter Info   
[10], [11], [8], [60], [61], [62]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[10], [11], [8], [63], [64], [41], [20]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Major    Inter Info   
[10], [11], [8], [48], [49], [50], [51], [52], [53], [54], [55], [56], [41]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[10], [11], [8], [65]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Major    Inter Info   
[10], [11], [8], [66]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[10], [11], [8], [67]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Major    Inter Info   
[10], [11], [8], [37], [68], [41]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[10], [69], [11], [8], [70], [71], [41]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Major    Inter Info   
[72], [73], [74], [10], [11], [8], [75], [76], [77], [78], [38], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Major    Inter Info   
[73], [10], [11], [8], [94], [95], [96]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Major    Inter Info   
[97], [10], [11], [8], [98], [99], [100], [101], [102]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Major    Inter Info   
[10], [11], [8], [103], [104], [105], [106], [107], [108], [41]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Major    Inter Info   
[10], [11], [8], [109]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Major    Inter Info   
[10], [11], [8], [110], [41]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Major    Inter Info   
[8], [111], [41]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Major    Inter Info   
[10], [11], [8], [118], [41]
D1017
 
Methadone
 
C21H27NO
 
4095 
Major    Inter Info   
[10], [11], [8], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [41]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[10], [11], [8], [129]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Major    Inter Info   
[10], [11], [8], [131]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Major    Inter Info   
[10], [11], [8], [48], [49], [50], [51], [52], [53], [54], [55], [56], [41]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Major    Inter Info   
[10], [11], [8], [48], [49], [50], [51], [52], [53], [54], [55], [56], [41]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[135], [136], [10], [11], [8], [137], [138]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Major    Inter Info   
[10], [11], [8], [48], [49], [50], [51], [52], [53], [54], [55], [56], [41]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Major    Inter Info   
[73], [10], [11], [8], [139], [140], [77], [38], [80], [141], [81], [82], [142], [84], [85], [86], [87], [143], [91], [96], [144]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Major    Inter Info   
[10], [11], [8], [133]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Major    Inter Info   
[10], [11], [8], [179]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Major    Inter Info   
[10], [11], [8], [37], [180], [41]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Moderate    Inter Info   
[8], [192], [193]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[8], [192], [193]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[8], [192], [193]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[8], [192], [193]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0636
 
Famotidine
 
C8H15N7O2S3
 
5702160 
Moderate    Inter Info   
[11], [8], [361]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0738
 
Granisetron
 
C18H24N4O
 
5284566 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0751
 
Halothane
 
C2HBrClF3
 
3562 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D0948
 
Lopinavir
 
C37H48N4O5
 
92727 
Moderate    Inter Info   
[8], [192], [193]
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[11], [8], [375]
D1181
 
Ondansetron
 
C18H19N3O
 
4595 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1254
 
Perflutren
 
C3F8
 
6432 
Moderate    Inter Info   
[383], [384]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[395], [396], [397], [398], [399], [400], [401], [402], [403], [404]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[8], [187], [188], [189], [190], [191], [192], [193]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Minor    Inter Info   
[11], [438], [439], [440]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Minor    Inter Info   
[10], [11], [8], [441], [442], [443], [444]
   Increased risk of ventricular arrhythmias Drug Num:  32
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[10], [11], [8], [19], [20]
D0868
 
Ivabradine
 
C27H36N2O5
 
132999 
Major    Inter Info   
[8], [23], [24]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Major    Inter Info   
[58], [59]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Moderate    Inter Info   
[11], [8], [209]
D0731
 
Glycerin
 
C3H8O3
 
753 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D0887
 
Lactitol
 
C12H24O11
 
157355 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[230], [231], [232]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[8], [270], [271]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[8], [270], [271]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[11], [8], [209]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[8], [270], [271]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[230], [231], [232]
D0025
 
Adenosine
 
C10H13N5O4
 
60961 
Moderate    Inter Info   
[10], [291], [11], [8], [292], [293], [294], [60], [295], [296]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[230], [231], [232]
D0888
 
Lactulose
 
C12H22O11
 
11333 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Moderate    Inter Info   
[10], [11], [8], [207], [208], [209]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[230], [231], [232]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [230], [252], [253], [254], [255], [256], [257], [258], [259], [260], [231], [261], [262], [232], [263], [264], [265]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[11], [8], [417]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1375
 
Radium Ra 223 dichloride
 
NA
 
NA
Major    Inter Info   
[11], [8], [36]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1756
 
Capromab pendetide
 
C10H15N5O11P2
 
135509147 
Moderate    Inter Info   
[306]
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109 Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
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111 Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
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180 Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
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189 Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
190 Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
191 Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
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193 Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
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201 Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
202 Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
203 Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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216 Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
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253 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
254 Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
255 Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
256 Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
257 Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
258 Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
259 Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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266 Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
267 Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
268 Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
269 Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
270 Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
271 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
272 Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
273 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
274 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
275 Gilead Sciences, Inc "About Remdesivir.".
276 US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
277 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
278 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
279 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
280 Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
281 Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
282 Product Information. Uptravi (selexipag). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
283 Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
284 Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
285 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
286 Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
287 Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
288 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
289 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
290 Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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307 Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
308 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
309 Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
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323 Multum Information Services, Inc. Expert Review Panel.
324 Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
325 Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
326 Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
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347 Product Information. Cafergot (caffeine-ergotamine). Novartis Pharmaceuticals, East Hanover, NJ.
348 Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
349 Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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356 Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
357 Skinner MH, Kuan HY, Pan A, et al. "Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers." Clin Pharmacol Ther 73 (2003): 170-7. [PMID: 12621382]
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360 Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
361 Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
362 Kantola T, Backman JT, Niemi M, Kivisto KT, Neuvonen PJ "Effect of fluconazole on plasma fluvastatin and pravastatin concentrations." Eur J Clin Pharmacol 56 (2000): 225-9. [PMID: 10952477]
363 Product Information. Lescol (fluvastatin). Novartis Pharmaceuticals, East Hanover, NJ.
364 Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
365 Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
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368 Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
369 Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
370 Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
371 Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
372 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
373 Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
374 Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
375 Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
376 Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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379 Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
380 Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
381 Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
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384 Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
385 Aquilante CL, Kosmiski LA, Bourne DW, et al. "Impact of the CYP2C8 *3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone." Br J Clin Pharmacol 75 (2013): 217-26. [PMID: 22625877]
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390 Product Information. Actos (pioglitazone) Takeda Pharmaceuticals America, Lincolnshire, IL.
391 Scheen AJ "Pharmacokinetic interactions with thiazolidinediones." Clin Pharmacokinet 46 (2007): 1-12. [PMID: 17201456]
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395 Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
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413 Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.
414 Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
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416 Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
417 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
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421 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
422 Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
423 Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ "Human hepatic cytochrome p450 2c9 catalyzes the rate-limiting pathway of torsemide metabolism." J Pharmacol Exp Ther 272 (1995): 1076-81. [PMID: 7891318]
424 Product Information. Demedex (torsemide). Boehringer Mannheim, Gaithersburg, MD.
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427 Cerner Multum, Inc. "Canadian Product Information.".
428 Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
429 European Medicines Agency Pharmacovigilance Risk Assessment Committee "PRAC recommendations on signals. Adopted at the PRAC meeting of 8-11 September 2014".
430 Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
431 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
432 Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
433 Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
434 Product Information. Briviact (brivaracetam). UCB Pharma Inc, Smyrna, GA.
435 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
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439 Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
440 Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
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446 Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.